A Systematic Approach to the Synthesis of Small Molecules for Potential Anti-Cancer Activity

Tyler Lengerich University of Saint Francis
Faculty Sponsor(s): Dennis Roberts University of Saint Francis
Several compounds with similar scaffolding can inhibit the glycolytic pathway. Due to cancer cells having an upregulation of glucose transporter proteins (GLUT), they are more sensitive to changes in the glycolytic process. We developed small molecules that contain these scaffolds with the idea that they too will inhibit the glycolytic pathway. We varied the molecules by incorporating the use of electron donating, electron withdrawing, hydrophobic, and hydrophilic functional groups. Although these compounds haven’t been tested for biological activity, we plan to modify the structure further once it is determined which functional groups have the greatest effect.
Chemistry
Oral Presentation

When & Where

09:00 AM
Gallahue Hall 101