Developing Site Specific DNA Binding Agents Using Novel Purine Analogs

Ashton Bosler University of Evansville
Faculty Sponsor(s): Roslyn Lampkins University of Evansville
Our research group uses the principles of supramolecular chemistry to develop new therapeutic DNA minor groove binders using purinyl amino acid building blocks. Sequence specific DNA minor groove binders have been found to act as cancer therapies and antimicrobials. They compete with transcription factor binding and can inhibit or activate specific gene expression. Minor groove binders even hold promise in suppressing genetic abnormalities.
Chemistry
Oral Presentation

When & Where

09:30 AM
Gallahue Hall 101