Analysis of Strain-specific Stability Among Human Metapneumovirus (hMPV) Clinical Isolates

Jenna Nosek Butler University
Faculty Sponsor(s): Christopher Stobart Butler University
Human Metapneumovirus (hMPV) is negative sense, single-stranded RNA virus from the newly formed family of Pneumoviridae. hMPV is a major cause of acute lower respiratory tract infections in young children and the elderly. Despite a global clinical burden of this virus, there remain no vaccines for hMPV and little is known of strain-specific differences among clinical isolates and laboratory strains. We recently demonstrated using respiratory syncytial virus (RSV) that appreciable differences in replication and physical stability exist among RSV strains. We hypothesize that significant differences in stability will also be observed among diverse hMPV strains. To test this hypothesis, we evaluated the replication kinetics and physical stability of a panel of hMPV clinical isolates. These studies provide the first detailed analysis of strain-specific differences among hMPV isolates and have implications for improving public health practices to limit the spread of and providing guidance on selection of strains for the development of future live-attenuated vaccine preparations targeting hMPV.
Oral Presentation

When & Where

11:15 AM
Gallahue Hall 106