28. The Potential Anticarcinogenic Effects of Cranberry Juice on Multiple Model Systems

Megan Schroeder Butler University, Christina Candotti Butler University
Faculty Sponsor(s): Lindsay Lewellyn Butler University
Cancer is a disease that impacts millions of people a year. Fortunately, some natural compounds have been shown to lessen the effect of cancer without producing the severe side effects associated with most chemotherapies. Cranberries are rich in antioxidants which are associated with a decrease in cancer risk. Previous studies have also showed that cranberries have anti-cancer properties by inducing cellular death, reducing cellular proliferation, and modifying the cytokines and signal transduction pathways of 17 different cancer types. We wanted to expand on these previous results by determining the effect of cranberry juice treatment on multiple model systems. In this study, we assayed the effect of cranberry juice on the survival of normal fruit fly cultured S2 cells, on the invasive migration of the border cells in the developing egg chamber, and on the proliferation rate of both D. melanogaster and human cervical cancer (HeLa cells). Preliminary data suggest that although cranberry juice can be toxic at high doses, it is able to slow the rate of border cell migration without affecting the rate of cell proliferation. Future studies will be performed to verify these results and further explore the effect of cranberry juice treatment on cell proliferation and apoptosis.
Poster Presentation

When & Where

Irwin Library 3rd Floor