Umayr Shaikh Butler University, Julia Wilson Butler University, Azhar Dalal Butler University
Faculty Sponsor(s): Lindsay Lewellyn Butler UniversityProper regulation of the size of cellular structures is essential for the normal function of cells, and a scaling relationship is often seen between overall cell size and the size of organelles or other structures. For example, larger cells often have larger structures or more organelles than smaller cells. Although these scaling relationships have been observed, little is known about how they are established and maintained during tissue growth. We are using the developing egg chamber as a model system to study size scaling relationships throughout development. Growing in volume over the 14 stages of oogenesis, the egg chamber contains several structures whose relative growth can be readily monitored. We have chosen to initially focus on size scaling of the germline intercellular bridges, or ring canals, which connect the developing oocyte to the supporting nurse cells. We have found that ring canal size scales with egg chamber size in four Drosophila species (D. melanogaster, D. pseudoobscura, D. santomea, and D. yakuba). Similar analysis on a collection of 10 artificially selected D. melanogaster lines that produce either big eggs or small eggs suggests that the size scaling relationship observed across Drosophila species is also maintained when looking within a single species. Future studies will follow up on these data and begin to explore other cellular structures, such as nurse cell nuclei.
When & Where
Irwin Library 3rd Floor